Table of Contents
February 12, 2004
Volume 47, Issue 4
Pages 769-1074
About the Cover: Molecular modeling of overlayed trisubstituted acridine derivatives (mauve and green) complexed with G-quadruplex DNA (Harrison, R. J.; et al. J. Med. Chem. 2003, 46, 4463-4476).
2003 American Chemical Society Award in Industrial Chemistry
Inhibitors of Serine Proteases as Potential Therapeutic Agents: The Road from Thrombin to Tryptase to Cathepsin G
Bruce E. Maryanoff
pp 769–787Publication Date (Web): July 23, 2008 (Perspective)
DOI: 10.1021/jm030493t
Hi-Res PDF Letters
Synthesis of a 5-Methylindolyl-Containing Macrocycle That Displays Ultrapotent Grb2 SH2 Domain-Binding Affinity
Zhen-Dan Shi, Kyeong Lee, Chang-Qing Wei, Lindsey R. Roberts, Karen M. Worthy, Robert J. Fisher, and Terrence R. Burke, Jr.
pp 788–791Publication Date (Web): January 13, 2004 (Letter)
DOI: 10.1021/jm030440b
Articles
In Vitro Structure−Activity Relationship and in Vivo Studies for a Novel Class of Cyclooxygenase-2 Inhibitors: 5-Aryl-2,2-dialkyl-4-phenyl-3(2H)furanone Derivatives
Song Seok Shin, Youngjoo Byun, Kyung Min Lim, Jin Kyu Choi, Ki-Wha Lee, Joo Hyun Moh, Jin Kwan Kim, Yeon Su Jeong, Ji Young Kim, Young Hoon Choi, Hyun-Ju Koh, Young-Ho Park, Young Im Oh, Min-Soo Noh, and Shin Chung
pp 792–804Publication Date (Web): January 14, 2004 (Article)
DOI: 10.1021/jm020545z
Virtual Screening with Flexible Docking and COMBINE-Based Models. Application to a Series of Factor Xa Inhibitors
Marta Murcia and Angel R. Ortiz
pp 805–820Publication Date (Web): January 9, 2004 (Article)
DOI: 10.1021/jm030137a
Prediction of HIV-1 Integrase/Viral DNA Interactions in the Catalytic Domain by Fast Molecular Docking
Adeyemi A. Adesokan, Victoria A. Roberts, Keun Woo Lee, Roberto D. Lins, and James M. Briggs
pp 821–828Publication Date (Web): January 13, 2004 (Article)
DOI: 10.1021/jm0301890
Explorations of Peptide and Oligonucleotide Binding Sites of Tyrosyl-DNA Phosphodiesterase Using Vanadate Complexes
Douglas R. Davies, Heidrun Interthal, James J. Champoux, and Wim G. J. Hol
pp 829–837Publication Date (Web): January 13, 2004 (Article)
DOI: 10.1021/jm030487x
Undersulfated and Glycol-Split Heparins Endowed with Antiangiogenic Activity
Benito Casu, Marco Guerrini, Sara Guglieri, Annamaria Naggi, Marta Perez, Giangiacomo Torri, Giuseppe Cassinelli, Domenico Ribatti, Paolo Carminati, Giuseppe Giannini, Sergio Penco, Claudio Pisano, Mirella Belleri, Marco Rusnati, and Marco Presta
pp 838–848Publication Date (Web): January 8, 2004 (Article)
DOI: 10.1021/jm030893g
Antitumor Agents. 3. Design, Synthesis, and Biological Evaluation of New Pyridoisoquinolindione and Dihydrothienoquinolindione Derivatives with Potent Cytotoxic Activity
Adele Bolognese, Gaetano Correale, Michele Manfra, Antonio Lavecchia, Orazio Mazzoni, Ettore Novellino, Paolo La Colla, Giuseppina Sanna, and Roberta Loddo
pp 849–858Publication Date (Web): January 20, 2004 (Article)
DOI: 10.1021/jm030918b
A Selective AT2 Receptor Ligand with a γ-Turn-Like Mimetic Replacing the Amino Acid Residues 4−5 of Angiotensin II
Ulrika Rosenström, Christian Sköld, Gunnar Lindeberg, Milad Botros, Fred Nyberg, Anders Karlén, and Anders Hallberg
pp 859–870Publication Date (Web): January 17, 2004 (Article)
DOI: 10.1021/jm030921v
Discovery of a New Class of Anilinoquinazoline Inhibitors with High Affinity and Specificity for the Tyrosine Kinase Domain of c-Src
Patrick A. Plé, Tim P. Green, Laurent F. Hennequin, Jon Curwen, Michael Fennell, Jack Allen, Christine Lambert-van der Brempt, and Gerard Costello
pp 871–887Publication Date (Web): January 14, 2004 (Article)
DOI: 10.1021/jm030317k
Recognition of Privileged Structures by G-Protein Coupled Receptors
Kent Bondensgaard, Michael Ankersen, Henning Thøgersen, Birgit S. Hansen, Birgitte S. Wulff, and Robert P. Bywater
pp 888–899Publication Date (Web): January 14, 2004 (Article)
DOI: 10.1021/jm0309452
5-Fluorinated l-Lysine Analogues as Selective Induced Nitric Oxide Synthase Inhibitors
E. Ann Hallinan, Timothy J. Hagen, Arija Bergmanis, William M. Moore, Gina M. Jerome, Dale P. Spangler, Anna M. Stevens, Huey S. Shieh, Pamela T. Manning, and Barnett S. Pitzele
pp 900–906Publication Date (Web): January 13, 2004 (Article)
DOI: 10.1021/jm030348f
Conformer- and Alignment-Independent Model for Predicting Structurally Diverse Competitive CYP2C9 Inhibitors
Lovisa Afzelius, Ismael Zamora, Collen M. Masimirembwa, Anders Karlén, Tommy B. Andersson, Silvio Mecucci, Massimo Baroni, and Gabriele Cruciani
pp 907–914Publication Date (Web): January 13, 2004 (Article)
DOI: 10.1021/jm030972s
Effects of C2-Alkylation, N-Alkylation, and N,N‘-Dialkylation on the Stability and Estrogen Receptor Interaction of (4R,5S)/(4S,5R)-4,5-Bis(4-hydroxyphenyl)-2-imidazolines
Moriz von Rauch, Miriam Schlenk, and Ronald Gust
pp 915–927Publication Date (Web): January 8, 2004 (Article)
DOI: 10.1021/jm0309809
Computer-Aided Design, Synthesis, and Anti-HIV-1 Activity in Vitro of 2-Alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)- ones as Novel Potent Non-Nucleoside Reverse Transcriptase Inhibitors, Also Active Against the Y181C Variant
Rino Ragno, Antonello Mai, Gianluca Sbardella, Marino Artico, Silvio Massa, Chiara Musiu, Massimo Mura, Flavia Marturana, Alessandra Cadeddu, and Paolo La Colla
pp 928–934Publication Date (Web): January 8, 2004 (Article)
DOI: 10.1021/jm0309856
Structural Basis for the Synthesis of Indirubins as Potent and Selective Inhibitors of Glycogen Synthase Kinase-3 and Cyclin-Dependent Kinases
Panagiotis Polychronopoulos, Prokopios Magiatis, Alexios-Leandros Skaltsounis, Vassilios Myrianthopoulos, Emmanuel Mikros, Aldo Tarricone, Andrea Musacchio, S. Mark Roe, Laurence Pearl, Maryse Leost, Paul Greengard, and Laurent Meijer
pp 935–946Publication Date (Web): January 8, 2004 (Article)
DOI: 10.1021/jm031016d
Ligand-Based Structural Hypotheses for Virtual Screening
Ajay N. Jain
pp 947–961Publication Date (Web): January 17, 2004 (Article)
DOI: 10.1021/jm030520f
Synthesis, SAR, Crystal Structure, and Biological Evaluation of Benzoquinoliziniums as Activators of Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Channels
Cécile Marivingt-Mounir, Caroline Norez, Renaud Dérand, Laurence Bulteau-Pignoux, Dung Nguyen-Huy, Bernard Viossat, Georges Morgant, Frédéric Becq, Jean-Michel Vierfond, and Yvette Mettey
pp 962–972Publication Date (Web): January 17, 2004 (Article)
DOI: 10.1021/jm0308848
Formation of Water-Soluble Pincer Silver(I)−Carbene Complexes: A Novel Antimicrobial Agent
Abdulkareem Melaiye, Richard S. Simons, Amy Milsted, Francesco Pingitore, Chrys Wesdemiotis, Claire A. Tessier, and Wiley J. Youngs
pp 973–977Publication Date (Web): January 14, 2004 (Article)
DOI: 10.1021/jm030262m
Synthesis of Mono- and Bisdihydrodipyridopyrazines and Assessment of Their DNA Binding and Cytotoxic Properties
Stéphanie Blanchard, Ivan Rodriguez, Christelle Tardy, Brigitte Baldeyrou, Christian Bailly, Pierre Colson, Claude Houssier, Stéphane Léonce, Laurence Kraus-Berthier, Bruno Pfeiffer, Pierre Renard, Alain Pierré, Paul Caubère, and Gérald Guillaumet
pp 978–987Publication Date (Web): January 17, 2004 (Article)
DOI: 10.1021/jm0309351
Jatrophane Diterpenes as Modulators of Multidrug Resistance. Advances of Structure−Activity Relationships and Discovery of the Potent Lead Pepluanin A
Gabriella Corea, Ernesto Fattorusso, Virginia Lanzotti, Riccardo Motti, Pierre-Noël Simon, Charles Dumontet, and Attilio Di Pietro
pp 988–992Publication Date (Web): January 13, 2004 (Article)
DOI: 10.1021/jm030951y
Design, Synthesis, and Biological Characterization of Metabolically Stable Selective Androgen Receptor Modulators
Craig A. Marhefka, Wenqing Gao, Kiwon Chung, Juhyun Kim, Yali He, Donghua Yin, Casey Bohl, James T. Dalton, and Duane D. Miller
pp 993–998Publication Date (Web): January 13, 2004 (Article)
DOI: 10.1021/jm030336u
Synthesis of Flexible Sulfur-Containing Heteroarotinoids That Induce Apoptosis and Reactive Oxygen Species with Discrimination between Malignant and Benign Cells
Shengquan Liu, Chad W. Brown, K. Darrell Berlin, Aridam Dhar, Suresh Guruswamy, David Brown, Ginger J. Gardner, Michael J. Birrer, and Doris M. Benbrook
pp 999–1007Publication Date (Web): January 9, 2004 (Article)
DOI: 10.1021/jm030346v
Novel Heteroarotinoids as Potential Antagonists of Mycobacterium bovis BCG
Chad W. Brown, Shengquan Liu, Jozef Klucik, K. Darrell Berlin, Patrick J. Brennan, Devinder Kaur, and Doris M. Benbrook
pp 1008–1017Publication Date (Web): January 9, 2004 (Article)
DOI: 10.1021/jm0303453
Prediction of Ligand Binding Affinity and Orientation of Xenoestrogens to the Estrogen Receptor by Molecular Dynamics Simulations and the Linear Interaction Energy Method
Marola M. H. van Lipzig, Antonius M. ter Laak, Aldo Jongejan, Nico P. E. Vermeulen, Mirjam Wamelink, Daan Geerke, and John. H. N. Meerman
pp 1018–1030Publication Date (Web): January 13, 2004 (Article)
DOI: 10.1021/jm0309607
Preparation, Properties, Reactions, and Adenosine Receptor Affinities of Sulfophenylxanthine Nitrophenyl Esters: Toward the Development of Sulfonic Acid Prodrugs with Peroral Bioavailability
Luo Yan and Christa E. Müller
pp 1031–1043Publication Date (Web): January 10, 2004 (Article)
DOI: 10.1021/jm0310030
Inhibition of Adenosine Deaminase by Novel 5:7 Fused Heterocycles Containing the Imidazo[4,5-e][1,2,4]triazepine Ring System: A Structure−Activity Relationship Study
Ayub Reayi and Ramachandra S. Hosmane
pp 1044–1050Publication Date (Web): January 13, 2004 (Article)
DOI: 10.1021/jm0304257
Macrocyclic Polyamines Deplete Cellular ATP Levels and Inhibit Cell Growth in Human Prostate Cancer Cells
Benjamin Frydman, Subhra Bhattacharya, Aparajita Sarkar, Konstantin Drandarov, Sergiy Chesnov, Armin Guggisberg, Kasim Popaj, Sergey Sergeyev, Aysil Yurdakul, Manfred Hesse, Hirak S. Basu, and Laurence J. Marton
pp 1051–1059Publication Date (Web): January 14, 2004 (Article)
DOI: 10.1021/jm030437s
Phe-Gly Dipeptidomimetics Designed for the Di-/Tripeptide Transporters PEPT1 and PEPT2: Synthesis and Biological Investigations
Jon Våbenø, Tore Lejon, Carsten Uhd Nielsen, Bente Steffansen, Weiqing Chen, Hui Ouyang, Ronald T. Borchardt, and Kristina Luthman
pp 1060–1069Publication Date (Web): January 06, 2004 (Article)
DOI: 10.1021/jm031022+
Full Text HTML Brief Articles
Importance of Phenolic Address Groups in Opioid Kappa Receptor Selective Antagonists
James B. Thomas, Scott E. Fix, Richard B. Rothman, S. Wayne Mascarella, Christina M. Dersch, Buddy E. Cantrell, Dennis M. Zimmerman, and F. Ivy Carroll
pp 1070–1073Publication Date (Web): January 8, 2004 (Brief Article)
DOI: 10.1021/jm030467v
Book Reviews
Compendium of Organic Synthetic Methods. Volume 11 By Michael B. Smith. John Wiley & Sons, Hoboken, NJ. 2003. xx + 795 pp. 16 × 24 cm. ISBN 0-471-25965-9. $225.00.
Thomas E. Prisinzano
p 1074Publication Date (Web): January 13, 2004 (Book Review)
DOI: 10.1021/jm030578u